Neurostimulatory and antioxidative effects
of L-deprenyl in aged rat brain regions
by
Kaur J, Singh S, Sharma D, Singh R.
School of Life Sciences, Neurobiology Laboratory,
Jawaharlal Nehru University, New Delhi, 110 067, India;
Present address: Seton Hall Unversity,
Center for Neuroscience,
Mcquaid Hall, 400 South Orange Avenue,
South Orange, NJ 07079, USA.
Biogerontology. 2003;4(2):105-11

ABSTRACT

This study investigated the influence of chronically administered L-deprenyl on normal ageing-related parameters: multiple unit action potentials, the activities of the enzymes Na(+),K(+)-adenosine triphosphatase, glutathione-s-transferase and glutathione peroxidase, and the levels of lipid peroxidation products and lipofuscin contents in the brain regions (cerebral cortex, hippocampus, striatum and thalamus) of 24-month-old rats. The drug increased the activity of Na(+),K(+)-ATPase and glutathione-s-transferase. The activity of glutathione peroxidase remained unaffected. The drug also increased the multiple unit action potentials activity. The levels of lipid peroxidation products were, however, decreased, and lipofuscin accumulation was diminished by the drug. The results essentially indicated that chronic treatment of rats with L-deprenyl significantly influenced the ageing-related alterations in: multiple unit action potentials, Na(+),K(+)-adenosine triphosphatase, glutathione-s-transferase, lipid peroxidation products and lipofuscin accumulation. These novel data on the effect of L-deprenyl on parameters of normal ageing provide new additional evidence concerning the anti-ageing therapeutic potential of L-deprenyl.

Drive
Ageing
Review
Structure
Interactions
Cytochrome P450
Alzheimer's disease
Selegiline and the brain
Selegiline and nitric oxide
Selegiline / neuroprotection
Selegiline and life-expectancy
Selegiline for longer-lived flies
Selegiline: product information
Selegiline as an immunostimulant
Selegiline for cocaine dependence
Aging, longevity drugs and eternal youth

Refs
and further reading

HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World

The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family