Safety of selegiline with cold medications
by
Jacob JE, Wagner ML, Sage JI.
Jeena E Jacob, PharmD Student,
Ernest Mario School of Pharmacy,
Rutgers, the State University of New Jersey,
Piscataway, NJ
Ann Pharmacother 2003 Mar;37(3):438-41

ABSTRACT

OBJECTIVE: To evaluate the safety of the coadministration of selegiline with cold medications. DATA SOURCES: Clinical literature accessed through MEDLINE (1965 -September 2002), IPA database, and Drug-Reax System. The following search terms were used: selegiline, pseudoephedrine, dextromethorphan, MAOI, and drug interactions. Somerset Pharmaceuticals, the marketers of Eldepryl (selegiline HCl), were also contacted. DATA SYNTHESIS: Despite a warning against its concomitant use with pseudoephedrine and dextromethorphan, interactions with selegiline have not been reported. However, there have been reports of patients experiencing adverse events with related agents. CONCLUSIONS: Patients taking selegiline should try to avoid pseudoephedrine and dextromethorphan or use drugs without interaction potential. If selegiline is used with these medications, watch for adverse events or replace selegiline with another drug.

Safety
Structure
Metabolites
Interactions
Phenylethylamine
Parkinson's disease
Desmethylselegiline
Selegiline and the DAT
Selegiline and the brain
Selegiline and nitric oxide
Selegiline and life-expectancy
Selegiline for longer-lived flies

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