Trophic effects of selegiline on cultured dopaminergic neurons
by
Kontkanen O, Castren E
A.I. Virtanen Institute and Department of Psychiatry,
University of Kuopio, P.O. Box 1627,
70211, Kuopio, Finland.
Brain Res 1999 May 22; 829(1-2):190-2

ABSTRACT

MTrophic effects of the neuroprotective agent selegiline on cultured dopaminergic neurons were investigated and compared with the effects produced by brain derived neurotrophic factor (BDNF). Both treatments increased the total length of TH-positive neurites, but selegiline increased the average length of neuritic branches, whereas BDNF increased the formation of new branches. This trophic effect of selegiline may contribute to its action in neurodegenerative disease treatment.

Dopamine
Metabolites
Interactions
Desmethylselegiline
Selegiline and nitric oxide
Selegiline / neuroprotection
Selegiline and life-expectancy
Antidepressant/dopamine D1 receptors

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