Deprenyl and the relationship between its effects on spatial memory, oxidant stress and hippocampal neurons in aged male rats
by
Kiray M, Bagriyanik HA, Pekcetin C, Ergur BU,
Uysal N, Ozyurt D, Buldan Z.
Department of Histology & Embryology,
Dokuz Eylul University Medical School,
Balcova, Izmir 35340, Turkey.
muge.kiray@deu.edu.tr.
Physiol Res. 2005 May 24

ABSTRACT

Ooxidative stress may play a major role on the aging process and associated cognitive decline, therefore antioxidant treatment may alleviate age-related impairment in spatial memory. Cognitive impairment could also involve the age-related morphological alterations of hippocampal formation. The aim of this study is to examine the relationship between the effects of deprenyl, an irreversible monoamine-oxidase B inhibitor, on spatial memory by oxidant stress and total number of neurons in the hippocampus CA1 region of aged male rats. In this study 24 months old male rats were used. Rats were divided into control and deprenyl groups and injected for 21 days. Learning experiments were performed for six days in the Morris water maze. Spatial learning was significantly better in deprenyl-treated rats compared to saline-treated rats. Deprenyl treatment elicited a significant decrease of lipid peroxidation in prefrontal cortex, striatum and hippocampus regions and a significant increase of glutathione peroxidase activity in the prefrontal cortex and hippocampus. It was observed that deprenyl had no effect on the superoxide dismutase activity. The total neuron numbers in the hippocampus CA1 region were significantly higher in the deprenyl group than in the control group. In conclusion, we demonstrated that deprenyl increases spatial memory performance in aged male rats and this increase may be related to suppression of lipid peroxidation and alleviation of age-related decrease of the number of neurons in the hippocampus. The results of such studies may be useful in pharmacological modification of aging process.

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