Reduced cardiovascular effects of methamphetamine
following treatment with selegiline
by
Schindler CW, Gilman JP, Graczyk Z, Wang G, Gee WL.
Preclinical Pharmacology Section,
Behavioral Neuroscience Branch,
DHHS/NIH/NIDA Intramural Research Program,
5500 Nathan Shock Drive, 21224, Baltimore, MD, USA.
Drug Alcohol Depend. 2003 Nov 24;72(2):133-9

ABSTRACT

Selegiline is a specific MAO-B inhibitor. As MAO-B has been shown to be significantly involved in the metabolism of dopamine in certain regions of the primate brain, selegiline has been proposed for use in the treatment of drug addiction. Selegiline is also metabolized in vivo to l-methamphetamine. Therefore, when given in combination with psychostimulants such as d-methamphetamine, there is the potential for adverse effects. To study this possibility, squirrel monkeys were treated with chronic selegiline and tested with two doses of d-methamphetamine (0.1 and 1.0 mg/kg, i.v.). Following at least 7 days of treatment with once daily 0.3 mg/kg i.m. selegiline, the effects of methamphetamine on blood pressure and heart rate were no different than the effects of methamphetamine observed prior to selegiline treatment. However, following at least 10 days of treatment with 1.0 mg/kg i.m. selegiline, the effects of methamphetamine on blood pressure and heart rate were significantly reduced. Both methamphetamine and amphetamine were detected in plasma following chronic selegiline treatment. When monkeys were given an acute selegiline injection prior to methamphetamine, reduced cardiovascular effects were also seen. These results indicate that selegiline can be used safely even in combination with methamphetamine, as the cardiovascular effects of the drug combination were no greater than either drug alone, and were actually reduced at the higher selegiline dose.

MAOIs
Review
Selegiline
Selegiline N-oxide
Alzheimer's disease
Selegiline and MDMA
Selegiline and nitric oxide
Amphetamine metabolites
Selegiline / neuroprotection
Selegiline and life-expectancy
Selegiline as an immunostimulant
Selegiline enhances rodent erections

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