Remarkable Effect of Selegiline (L-Deprenyl), a Selective Monoamine Oxidase Type-B Inhibitor, in a Patient With Severe Refractory Depression: A Case Report
by
Higuchi H, Kamata M, Sugawara Y, Yoshida K.
From *Omagari City Hospital,
Omagari; the ‡Department of Neuro-Psychiatry,
Yuri Kumiai General Hospital, Honjyo; and the ‡ Department of Psychiatry,
Nagoya University Graduate School of Medicine, Japan.
Clin Neuropharmacol. 2005 July/August;28(4):191-192
ABSTRACTA 34-year-old man presented with severe refractory depression. He had failed to respond to various antidepressants, augmentation therapy with lithium carbonate, and modified electroconvulsive therapy. Switching from amoxapine 150 mg/day to selegiline 7.5 mg/day, a selective monoamine oxidase type-B inhibitor, produced a dramatic reduction in hypobulia and lassitude, leading to a complete remission of all depressive symptoms. The patient reverted to his former position at work after an interval of approximately 3 years. Although the biologic basis of the antidepressant effect of selegiline in this patient is unknown, it is suggested that the enhancement of dopaminergic neurotransmission or elevation of brain-derived neurotrophic factor levels in the brain by administration of selegiline is involved in the recovery of this patient from severe refractory depression. This report indicates the antidepressant effect of selegiline in a refractory depressed patient.EMSAM
Antiaging compounds
Selegiline and the DAT
Selegiline and nitric oxide
Selegiline and life-expectancy
Selegiline for longer-lived flies
Selegiline: product information
Selegiline and (-)-BPAP in major depression
MAOIs, transdermal selegiline and atypical depression
Feb 2006: EMSAM (selegiline transdermal system) licensed by FDAand further reading
Refs
HOME
HedWeb
Nootropics
cocaine.wiki
Future Opioids
BLTC Research
MDMA/Ecstasy
Superhapiness?
Utopian Surgery?
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World
The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family
